Job Description

About Glyphic:

At Glyphic Biotechnologies, we plan to create the protein revolution for which scientists and researchers have been waiting. We are developing a massively parallel, single-molecule proteome sequencing platform that will transform life science discovery and usher in a new era of insights into human biology and disease. To date, we have raised >$50M from venture partners and non-dilutive grant funding to achieve our vision of next generation proteome sequencing.

What we are looking for in you

Glyphic is seeking a (Senior) Director of Chemistry to lead Glyphics chemistry function designing novel reagents, driving sampleprep innovations, and building a worldclass chemistry team to deliver a disruptive singlemolecule protein sequencing technology. This is a fulltime, exempt, onsite position reporting to the Vice President of Research & Development. This is a fulltime, exempt, inperson position with work conducted at our Berkeley, CA location.

What youll do

• Set the longterm chemistry roadmap for protein sequencing (bio/ortho/conjugations, amino acid side chain modifications, N/Cterminal cleavage, surface chemistry, custom nucleosides, reagent development).
• Partner with biology, engineering, microfluidics/automation, and data science to ensure seamless platform integration.
• Drive intellectual property strategy, competitive landscape analysis, and participate with legal on freedomtooperate evaluations.
• Build robust blocking, capping, and wash chemistries to minimize crosstalk and background signal on solid supports, flow cells, or microarray surfaces, ensuring high specificity and sensitivity in downstream detection assays.
• Utilize highthroughput screening and combinatorial chemistry testbeds to develop robust and reproducible protocols
• Innovate frontend chemistries for protein/peptide capture, enrichment, and derivatization.
• Optimize lysis, digestion, and peptide stabilization protocols that preserve posttranslational modifications (PTMs) and support lowinput samples.
• Integrate with orthogonal proteomics (nano LCMS, ) for validation.
• Transition discoveryphase reagents to reagent manufacturing.
• Recruit, mentor, and lead a multidisciplinary chemistry team (synthetic, analytical, biochemical, biophysical).
• Define and track OKRs, budgets, and timelines to meet aggressive startup milestones.
• Foster a collaborative, datadriven culture and integrate closely with crossfunctional teams.

What you need

• PhD in organic chemistry, chemical biology, biochemistry, or related field.
• 12+ years in reagent or assay development, including 4+ years in leadership.
• Proven expertise in protein/peptide chemistry (synthesis, purification, bioconjugation)
• Strong background in sampleprep chemistry and methods for proteomics, ideally including immunopeptidomics
• Ability to develop novel nucleic acid chemistry (new base pairing, new phosphoramidites)
• Translate prototypical organic chemistry (photochemistry, redox chemistry) into a biological environment
• Proficiency with analytical techniques: HPLC, LCMS, fluorescence spectroscopy, NMR, etc
• Experience with Intellectual property strategy, competitive landscape analysis, freedomtooperate evaluations
• Track record of translating discoveryphase chemistry into scalable, manufacturingready or commercial reagents
• Prior startup or earlystage company experience.
• Visionary and handson leader who can balance strategic planning with benchlevel problem solving.

Nice to have

• Familiarity with singlemolecule or nextgeneration sequencing chemistries and assays
• Knowledge of photochemistry, peptide synthesis, amino acid blocking strategies, orthogonal labeling systems.
• Experience with automation and/or microfluidic reagent delivery systems
• History of patent filings and IP portfolio development.

Were looking for teammates with

• Excellent interpersonal skills capable of building strong relationships and communicating effectively with stakeholders at all levels.
• High emotional and analytical intelligence able to navigate complex team dynamics, partnerships, and challenges with creativity and logic.
• Resourceful adaptability operates with urgency, remains flexible in evolving environments, and thrives in ambiguity.
• Collaborative spirit enjoys working across disciplines and explaining complex concepts to diverse audiences.

What you can expect from this role

Work environment

• Collaborative culture where your ideas and expertise are valued; and bold, innovative thinking is encouraged
• Direct impact on product development and company direction
• Access to cuttingedge technology in a top tier life science facility

Professional growth

• Play a key role in producing patents and publications with significant impact on the field of biological research
• Opportunities for advancement and expanding responsibilities as the organization scales

Compensation

Estimated Base Salary $189,000 - $258,000

This is the pay range for this position that we reasonably expect to pay. Individual compensation is based on various factors including, experience, education, skillset, and geographic location. This range is for the SF Bay Area, California location and may be adjusted to the labor market in other geographic areas.

Benefits and Perks

• Employee Stock Option Plan
• 100% Health Plan Coverage for Employees & Dependents (Medical, Dental, & Vision)
• Employer Retirement Contributions to 401(k)
• Generous Paid Time Off
• Paid Maternity and Paternity Leave
• Health & Wellbeing Program
• Office Snacks and Beverages
• Regular Team Bonding Activities

We are an Equal Opportunity Employer. We celebrate diversity and are committed to creating an inclusive environment for all employees. Individuals seeking employment at Glyphic Biotechnologies are considered without regard to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, or sexual orientation.

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